My friend Craig Quilkey shares 5 things your organisation needs to focus on to maintain a culture of creativity
This collaboration is setting the stage for a transformative era in diagnosing and treating diseases, with profound implications for human health and medicine. Across a wide range of fields, from stem cell biology to gene therapy, the impact of these innovations is already being felt.
One of the most exciting breakthroughs in recent years has been in the area of gene therapy, particularly for previously devastating conditions like spinal muscular atrophy (SMA), which once carried a grim prognosis. Gene therapy has allowed scientists to deliver a "good" copy of the affected gene via a viral vector, effectively curing the disease through genomic medicine. This type of intervention marks a new frontier in medicine, where conditions that were once a death sentence can now be treated or even cured.
AI has further enhanced our ability to predict and diagnose diseases before symptoms appear, allowing for early intervention. As we continue to develop tools to read human DNA with increasing precision, the ability to identify the specific portions of DNA responsible for diseases will revolutionize personalized medicine.
The ability to sequence the human genome has been a game-changer. To date, around 50 million people have had their DNA sequenced, unlocking vast amounts of data that have provided invaluable insights into the causes of diseases. In the field of oncology, genome sequencing has helped pinpoint the genetic changes that drive cancer, allowing doctors to tailor treatments to individual patients. By comparing a patient's DNA with hundreds of thousands of others, data scientists can now identify patterns and predict the best possible treatment options.
Stem cell biology has also benefited from advances in AI. Scientists can now generate human cells using an individual's own cells, offering new opportunities to repair and regenerate damaged tissues. This development is particularly exciting in the context of drug development, where AI tools are being used to predict the efficacy of treatments. Historically, drug development has been hindered by a heavy reliance on animal models, which often prove poor predictors of how a treatment will work in humans. Stem cell technologies, coupled with AI, are now paving the way for more accurate, human-centric models.
AI has proven to be a powerful tool in the diagnosis of genetic diseases. In fact, AI tools have the capability to accurately diagnose 60-80% of genetic diseases, making these diagnoses more accessible to the general population. Through automation, the process of reanalyzing existing genetic data has become more efficient, leading to the identification of hundreds of new diseases that previously went undetected.
One of the most significant milestones in recent scientific research is the approval of the first CRISPR-based therapy, which uses molecular "scissors" to edit the human genome. This technology allows for the correction of genetic mutations at their source, offering hope for conditions such as sickle cell anemia, where CRISPR can be used to edit the hemoglobin gene.
This breakthrough marks the beginning of a new era in which scientists are pushing the boundaries of what is possible in human biology. Over the next five years, experts predict that gene editing technologies like CRISPR, combined with AI, will revolutionize the way we understand and treat diseases.
As genomic research expands, there has been an increased focus on ensuring that Indigenous populations are not left behind. The establishment of a Centre for Population Genomics, specifically focused on Indigenous communities, is an important step in addressing the ethical considerations of genomic research. National efforts, led by Indigenous groups, aim to ensure that genomic data is collected in a way that is both culturally sensitive and beneficial to these communities. However, skepticism remains about whether these efforts truly serve Indigenous populations, highlighting the need for continued dialogue and collaboration.
The convergence of AI, genomics, and data science is poised to drive the next wave of innovation in healthcare. Claire, a scientist originally from New Zealand, highlights the importance of proteins, the "engine room" of biology, in understanding the effects of genomic changes. By leveraging AI, scientists can analyze vast amounts of genomic data, predict the impact of genetic variations, and develop targeted therapies.
This interdisciplinary approach is not only transforming drug discovery but also heralding a more human-centric way of approaching medicine. Scientists are excited about the potential to bring together experts from diverse fields, creating a future where the interface between genomics, AI, and cell biology leads to unprecedented medical advancements.
In the coming years, the impact of AI and genomic science will continue to unfold, with dramatic implications for healthcare and beyond. As automation and AI-driven data analysis become more sophisticated, our ability to diagnose and treat diseases will become more accurate and accessible. The rapid pace of these developments suggests that within the next 12 months alone, we will witness groundbreaking advancements that will reshape the future of medicine.
Ultimately, the convergence of AI, genomics, and stem cell technologies offers a glimpse into a future where diseases can be diagnosed earlier, treated more effectively, and even cured. This revolution in scientific research represents a transformative shift in our ability to improve human health, making the next decade one of the most exciting times in the history of medicine.
The Panel
Sarah Murdoch is a champion of medical research and genomic medicine. Sarah is Co-Chair and Global Ambassador of Murdoch Children’s Research Institute (MCRI), one of the top three paediatric research institutions globally, where she has been dedicating her efforts for 25 years. Sarah has garnered numerous awards for her exceptional contributions to the not-for-profit sector, including the prestigious Celebrity Advocacy Award bestowed by Research Australia.
Professor Enzo Porrello is the Director of Stem Cell Medicine at the Murdoch Children's Research Institute. He is an expert in stem cell biology and regenerative medicine who leads the Heart Regeneration Group at the Murdoch Children's Research Institute. Enzo directs the Melbourne Node of the Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen) and also co-founded Dynomics, a biotechnology company that is developing treatments for heart failure using cardiac organoids.
Professor Daniel MacArthur is founding Director of the Centre for Population Genomics, a joint initiative of the Garvan Institute of Medical Research and the Murdoch Children's Research Institute. In his previous role at the Broad Institute of MIT and Harvard Daniel led the development of the Genome Aggregation Database (gnomAD), the largest collection of human DNA sequencing data in the world, which now includes >800,000 individuals and has been used in the analysis of over 2 million rare disease patients around the world. At the Centre for Population Genomics, Daniel leads a team of 40 working to build resources to create an equitable future for genomic medicine in Australia and beyond.
Dr Clare Bycroft is a research scientist, at Google DeepMind, a world-leader in developing artificial intelligence technology, and its application to a wide variety of areas including genomic science. Clare uses machine learning to tackle important challenges in human genetics, such as predicting the impact of genetic variation on biological processes that can contribute to disease. In previous roles, Clare helped build and analyse population-scale genetic and biomedical data, now routinely used to discover new drug targets.
Futurist Ben Hamer predicts the future of work to 2030!
Key takeouts
In Oz - unemployment is low 4.1%, with a diverse and multicultural workforce,
The aging workforce is a challenge, with Gen Z (1997-2012) making up 25% of our workers, but not enough talent to fill critical roles.
There is a great opportunity in finding talent from a large migrant population from India, many currently working below their skill level.
🤖 AI Adoption & Literacy:
But
💡 What Workers Want:
Workers just want good pay andd to not work for a dick!!
🔄 Challenges in Change: #f#ck transformation
🚫 Opting Out of Management:
The landscape is shifting—are you prepared to navigate these changes?
#FutureOfWork #AI #Leadership #WorkforceTrends #Transformation #HybridWork #EmployeeEngagement
